Oxygen intermediates and Inflammation

SnapShot: Reactive Oxygen Intermediates (ROI)

II . The Role of Oxygen Intermediates

In the accompanying report (1), we demonstrated that Toxoplasma gondii, an obligate intracellular parasite, is susceptible to oxygen intermediates generated by the xanthine oxidase system. The present study examines the contribution of oxidative metabolites to macrophage killing and inhibition of growth of intracellular T. gondii. Our observations indicate that an oxygen-dependent antimicrobial...

Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates.

BACKGROUND Mycobacterium tuberculosis is a significant human pathogen capable of replicating in mononuclear phagocytic cells. Exposure to reactive oxygen and nitrogen intermediates is likely to represent an important aspect of the life cycle of this organism. The response of M. tuberculosis to these agents may be of significance for its survival in the host. MATERIALS AND METHODS Patterns of ...

Reactive nitrogen and oxygen intermediates in patients with cutaneous leishmaniasis.

The metabolisms of reactive nitrogen and oxygen intermediates (RNI and ROI) in patients with cutaneous leishmaniasis (CL) were investigated and compared with those of healthy subjects. To determine RNI metabolism, nitrite plus nitrate concentrations were measured spectrophotometrically. Nitrite concentration in plasma was determined directly by the Griess method. Nitrate levels in plasma were m...

Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation

Although the exact mechanism through which NADPH oxidases (Nox's) generate reactive oxygen species (ROS) is still not completely understood, it is widely considered that ROS accumulation is the cause of oxidative stress in endothelial cells. Increasing pieces of evidence strongly indicate the role for ROS in endothelial inflammation and dysfunction and subsequent development of atherosclerotic ...